Low concentration of oxygen in the blood and tissues of people living at high altitudes is due to:

1. Low temperature
2. Low atmospheric pressure
3. High atmospheric pressure
4. Both low temperature and high atmospheric pressure

(a) Low concentration of oxygen in the blood and tissues of people living at high altitude is due to low atmospheric pressure. Because at high altitude, the partial pressure of oxygen is less than at the ground level. This decreased atmospheric pressure causes release of oxygen from blood.